Statistics Notes: Missing outcomes in randomised trials
نویسندگان
چکیده
منابع مشابه
Statistics notes: missing outcomes in randomised trials.
In most randomised trials, some patients fail to provide data for study endpoints. 1 We have previously described the analysis of a trial of acupuncture versus sham acupuncture for the treatment of shoulder pain. 2 All 52 randomised patients provided baseline data on pain and range of motion, but only 45 returned for follow-up testing. The statistical question is how to handle those seven patie...
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why depending on the rationality of the market will never work well for quality of care (box). Sensible policy for providing nursing home care requires a larger welfare state, a larger regulatory state, and encouragement of public, non-profit providers. Australia’s recent experience shows that to head in the opposite direction is medically, economically, and politically irrational. Competing in...
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Attrition is a common occurrence in cluster randomised trials which leads to missing outcome data. Two approaches for analysing such trials are cluster-level analysis and individual-level analysis. This paper compares the performance of unadjusted cluster-level analysis, baseline covariate adjusted cluster-level analysis and linear mixed model analysis, under baseline covariate dependent missin...
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Missing outcomes are a commonly occurring problem for cluster randomised trials, which can lead to biased and inefficient inference if ignored or handled inappropriately. Two approaches for analysing such trials are cluster-level analysis and individual-level analysis. In this study, we assessed the performance of unadjusted cluster-level analysis, baseline covariate-adjusted cluster-level anal...
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Human behaviour is influenced by what we know or believe. In research there is a particular risk of expectation influencing findings, most obviously when there is some subjectivity in assessment, leading to biased results. Blinding (sometimes called masking) is used to try to eliminate such bias. It is a tenet of randomised controlled trials that the treatment allocation for each patient is not...
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ژورنال
عنوان ژورنال: BMJ
سال: 2013
ISSN: 1756-1833
DOI: 10.1136/bmj.f3438